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Emily S. Wang

A New Light in Biosensing:
Engineering a Bright and Photostable Green Fluorescent Protein Mutant
for Fluorescence Resonance Energy Transfer (FRET)

Palo Alto, CA
Grade 12

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A New Light in Biosensing: Engineering a Bright and Photostable Green Fluorescent Protein Mutant for Fluorescence Resonance Energy Transfer (FRET)

The discovery and development of fluorescent proteins, recognized by the 2008 Nobel Prize in Chemistry, enabled a revolution in biological imaging and sensing. Biosensors employing energy transfer between fluorescent proteins are powerful tools to non-invasively report biochemical events at the molecular level. I engineered a new fluorescent protein Clover3, which is the brightest monomeric fluorescent protein to date. To understand mechanisms of illnesses, researchers can use Clover3 as a biological tool to illuminate cancer and neurological disease pathways. With its superior optical characteristics, Clover3 can benefit diverse medical applications, such as visualizing cancer metastases and imaging neural structures.

 

   
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The National Gallery for America's Young Inventors ™ is the only nationally recognized hall of fame for student inventors, established in 1993 and given permission by the adult National Inventors Hall of Fame Board in Washington, D.C. to archive and enshrine great student inventions and inventors K-12.


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