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Steven Wang & Andrew Jin

Novel Computational Framework for the
Discovery of Synergistic Chemotherapy Combinations (Team)


Los Altos Hills, CA & San Jose, CA
Grade 12

 

Novel Computational Framework for the Discovery of Synergistic Chemotherapy Combinations (Team)

The Novel Computational Framework for the Discovery of Synergistic Chemotherapy Combinations is an interdisciplinary rational design framework combining computational predictions with in-vitro validation and optimization studies to facilitate the efficient discovery of potentially groundbreaking synergistic drug pairs. When two agents synergize, they enhance the efficacies of one another, leading to a combined outcome that is greater than the sum of the individual outcomes. As a result, the probability of drug resistance is substantially reduced, and increased efficacy can be attained at lower doses and toxicity levels.

 

   
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 We gratefully acknowledge the generous support of the Christopher Columbus Fellowship Foundation for the National Gallery of America's Young Inventors, 1999-2006

Christopher Columbus Fellowship Foundation

 
   

The National Gallery for America's Young Inventors ™ is the only nationally recognized hall of fame for student inventors, established in 1993 and given permission by the adult National Inventors Hall of Fame Board in Washington, D.C. to archive and enshrine great student inventions and inventors K-12.


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