Characterization of the MerTK Nuclear Pathway-Kinase Activity Link as a Potential Target Demonstrating Reduced Anchorage-Independent Cancer Growth
Sally Nijim
Villa Park, IL
Age 18
This research (1) identified the presence of a link between the MerTK nuclear pathway mechanism and MerTK kinase activity contributing to anchorage-independent cancer growth; (2) produced nuclear localization sequence mutations that significantly reduce cancer colony formation; and (3) produced knockout cell lines embodying mutations in such nuclear localization sequences to reduce cancerous colony formation. Such research characterized the existence of a link between MerTK’s nuclear pathway and kinase activity contributing to such cancers as ALL.